From discovery to production: Scale-out of continuous flow meso reactors

From discovery to production: Scale-out of continuous flow meso reactors

A continuous flow parallel reactor system has been developed to provide a rapid and seamless transition from the discovery phase and production phase of chemical synthesis, particularly in low volume-high value pharmaceuticals production. Using a single fixed bed catalytic meso reactor, reactions can be screened on a small discovery scale over short time scales. The intensified process produces...

Continuous formation of N-chloro-N,N-dialkylamine solutions in well-mixed meso-scale flow reactors

The continuous flow synthesis of a range of organic solutions of N,N-dialkyl-N-chloramines is described using either a bespoke meso-scale tubular reactor with static mixers or a continuous stirred tank reactor. Both reactors promote the efficient mixing of a biphasic solution of N,N-dialkylamine in organic solvent, and aqueous sodium hypochlorite to achieve near quantitative conversions, in 72-...

Sustainable Production of Pharmaceutical Drugs Using Continuous Flow Reactors

The current trend in the pharmaceutical industry is towards continuous flow processes. The objective of this project is to provide the pharmaceutical industry with a technology roadmap to implement continuous flow processes to their manufacturing operations. Reducing economic and environmental costs is the driving force behind this trend. Continuous flow technology can produce a cheaper better ...

Towards Integrated Continuous-Flow Chemical Reactors

A device for rapid mixing of two solutions is presented. As the main mechanism for mixing is diffusional mass transport, the ̄ow has to be split into several laminae which are narrower than the capillary width. Complete mixing is achieved within a few seconds in a ̄ow-through device with a channel system that is 600mm wide at its narrowest spot.

Continuous Flow Manufacturing for API: From Potential Evaluation to Production Scale Realization